RotaChrom Blog Highlights
Selected articles from our legacy blog. Click any card to read the full post.
Scale-Up or Scale-Out? Choosing the Right Strategy for Increasing Purification Capacity
As purification demands grow from laboratory development toward pilot and industrial production, one of the first questions process engineers face is simple: How can production capacity be increased without sacrificing separation performance? This article explains the difference between scale-up and scale-out in CPC, and why parallel purification, also known as farming, can be an attractive strategy for increasing production capacity.
July 30 , 2026 · News
Understanding CPC Operation Modes: Ascending, Descending and Multiple Dual-Mode
Choosing the right operating mode is one of the most important decisions in Centrifugal Partition Chromatography (CPC) method development. Solvent-system selection and partition coefficients (Kd) determine whether a separation is chemically feasible. However, the operating mode determines how that partition behavior is translated into an actual chromatographic process.
July 28 , 2026 · News
CPC Simulator: A digital tool for effective method development
Developing a successful Centrifugal Partition Chromatography (CPC) method often requires extensive solvent screening, multiple laboratory experiments and significant development time. RotaChrom Technologies introduced the CPC Simulator through webinar, an in-house developed software platform designed to simplify CPC process development through predictive modeling and chromatography simulation.
July 14, 2026 · News
How to run a feasibility study on CPC
Feasibility study or FST, is the first practical steps in CPC (Centrifugal Partition Chromatography) method development.The feasibility study starts with understanding the starting material and the target compound. This includes the starting material, target compound, impurity profile, available analytical method and expected outcome.
July 2, 2026 · News
From Solvent Selection to Robust CPC Method Development
Successful CPC purification is the result of a carefully developed method rather than a single experimental decision. After a promising biphasic solvent system has been identified, the next step is to understand how the target compound and its impurities behave within that system under realistic operating conditions.
June 24, 2026 · News
Choosing the Right Solvent System
A well-designed solvent screening strategy can significantly reduce development time while improving purification efficiency and process robustness. HEMWat and Arizona systems, and predictive development tools help identify the optimal separation environment faster and more efficiently.
June 17, 2026 · News
From extraction to purification
Understanding liquid-liquid extraction (LLE), liquid-liquid chromatography (LLC) and centrifugal partition chromatography (CPC). Where does extraction end and purification begin? This article explores the key differences between LLE, LLC and CPC, and explains why modern pharmaceutical manufacturing increasingly relies on integrated downstream purification strategies to achieve high purity, scalability and process efficiency.
June 12, 2026 · News
Why downstream purification and scale-up are slowing pharmaceutical innovation
The bottleneck in many pharmaceutical processes is no longer discovery but to improve purity, yield, sustainability, regulatory compliance and speed-to-market all while managing rising operational costs and increasingly complex production workflows.
June 4, 2026 · News
Continuous Chiral CPC in practice
A cyclodextrin-mediated chiral CPC(centrifugal partition chromatography) process was developed for rac-voriconazole and successfully intensified from batch to cyclic continuous and continuous
April 4, 2026 · Publication
Regulatory & Standards Compliance Guide for Industrial CPC Systems
RotaChrom has published the “Regulatory and Standards Compliance Guide for CPC Systems”, providing a practical overview of how compliance is built into every stage of CPC system development.
January 12, 2026 · Application Note, Download
RotaChrom and Inkarp Partner to Bring Industrial-Scale CPC to India
The article highlights the strategic partnership between RotaChrom and Inkarp, bringing industrial-scale CPC solutions to India’s pharmaceutical, biotechnology, and research sectors.
July 30, 2025 · News
Red Mesa Sets the Standard in Cannabinoid Purification with Industrial-Scale CPC
The article showcases the partnership between Red Mesa Science & Refining and RotaChrom Technologies, highlighting the use of industrial-scale CPC for high-purity cannabinoid production.
July 9, 2025 · News
Comparing MCSGP and Centrifugal Partition Chromatography
MCSGP and CPC compared side-by-side as powerful purification technologies in modern chromatography.
March 16, 2025 · News
Advancing Separation Science: CPC Device Installation and Its Impact
How CPC implementation improves efficiency and robustness in complex separation workflows.
April 17, 2025 · News
Reflecting on GA 2025
Our team had the privilege of attending the 73rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), jointly organized with the Italian Society of Phytochemistry (SIF) in Naples.
Setember 9, 2025 · Events
RotaChrom at Flow Chemistry Europe 2025
Highlights from FCE-25 in Málaga and how CPC technology shaped the discussions on innovative flow chemistry.
April 16, 2025 · Events, News
Optimizing Chromane Epoxide Separation for Nebivolol Synthesis with Chromatography
A closer look at Nebivolol synthesis and how CPC enables precise, scalable separation of key intermediates.
January 24, 2025 · Download, Education, News
SZTE’s Award-Winning Innovation: A Natural Breakthrough in Obesity Prevention
An award-winning collaboration showcasing how advanced purification can support the discovery of novel compounds in obesity research.
February 4, 2025 · Education, News, Studies
Innovations in Chiral Purification: Exploring Techniques and Future Potential
An in-depth look at modern chiral separation strategies and how CPC fits into the future of enantiomeric purification.
January 31, 2025 · Download, Education, News