Cosmetics and fragrances

Discover the power of centrifugal partition chromatography in separating challenging diastereomers! In this application note, we delve into the intricacies of separating an odorant diterpene from its epimer, a task previously deemed difficult with traditional methods. Learn how this innovative technique resolves the separation challenge, providing a cost-effective solution for isolating synthetically produced perfume ingredients. Don’t miss out on this fascinating exploration of chromatography advancements!

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Preparative separation of epimer diterpenes

Goal: Separation of epimers

Ratio of epimers in the starting material: 7:3

The Compound of Interest is a synthetically produced perfume ingredient. It’s important to note that this separation was yet to be solved cost-effectively by either column chromatography or fractional distillation. The selectivity value between the CoI and its epimer (1.59) in the selected solvent system is unprecedentedly high in the field of small molecule and chromatographic epimer separation. Selectivity of this scale typically requires chiral stationary phase, which adds significant additional costs.

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