TECHNOLOGY
Scientific Value
Explore our technology and how it empowers your purification process
For chemists, CPC offers a highly selective and truly scalable purification solution. The CPC is seamlessly adaptable from early research and development through to full-scale industrial production. It maintains high resolution and efficiency at every stage, without introducing delays, compromising purity, or driving significantly growing up costs. It’s a purification technology that grows with your process, and supporting your science at every step.
About Centrifugal Partition Chromatography (CPC):
How CPC works and why it matters in purification.
Centrifugal Partition Chromatography (CPC) is a liquid–liquid chromatography technique that dispenses with solid stationary phases, using immiscible liquids instead. The stationary phase is held in place by centrifugal force while the mobile phase carries compounds through the rotor’s interconnected cell chambers. Separation is based on each molecule’s partition coefficient, offering high resolution without issues like irreversible adsorption or silica degradation.
No Solid Phase, No Silica
Eliminate issues like irreversible adsorption, peak tailing, or column fouling. No silica means more reproducible results.
No Column Degradation
Without a silica-based stationary phase, there’s no risk of compaction, degradation, or performance loss, even under challenging conditions (like pH modification) for improved selectivity or purity.
Wide Solvent Compatibility
Choose from hundreds of biphasic, multi-component solvent system combinations to fine-tune selectivity and maximize purity.
High Recovery Rates
Gentle separation without heat or pressure preserves sensitive molecules and maximizes yield.
Excellent Loadability
CPC’s high stationary phase retention and adjustable mobile-to-stationary phase ratio support large injection volumes while maintaining separation performance.
Green Chemistry Ready
Lower solvent consumption, option for greener solvent systems, and high reusability make CPC a more sustainable choice.
Scalable Without Redesigning
Keep your method and scale your volume, from mg to hundreds of kg, without changing purification method and phases or column formats.
Process
Rotation &Centrifugal Force
Mechanism
Stationary vs.Mobile Phase
Separation
High ResolutionSeparation
Multiple Dual-Mode CPC:
Effective Continuous Processing in Chromatography
Continuous processing has also been adopted in liquid-liquid chromatography, improving productivity and enhancing its industrial applicability while reducing buffer, solvent, and raw material consumption within a smaller footprint. By using one or two CPC units in multiple dual-mode (MDM), continuous operation is possible, enabling higher throughput, increased productivity, improved solvent utilization, and significantly more effective scale-up.
Wide-Range Applicability
Efficient isolation, separation and purification processes from laboratory to industrial levels in the chemical, life science, natural extract, specialty chemical, and pharmaceutical industries.
Solution for Challenging Separations
Highly effective and versatile solution for addressing challenges related to selectivity of complex separations involving closely eluting components.
Continuous Injection
Significantly enhance overall productivity by ensuring a continuous flow of samples, increasing throughput and productivity.
Reduced Purification Time
Optimized parameters for faster isolation of target compounds without compromising purity.
OPERATION
Dual-rotorGoal
Isolation, SeparationPurification
PRODUCTION
Continuous manufacturing
Feasibility & Method Evaluation:
How a feasibility study works, Kd measurements, challenges.
Our process starts with solvent system screening, using your crude sample to identify biphasic solvent systems in which all components are fully soluble. Once solubility is confirmed, we measure partition coefficients (Kd) and assess compound distribution between phases. The result is a data-driven assessment, “can CPC work for your CoI, and how well?”, giving you method viability before moving forward. CPC excels at resolving isomers, and other closely related compounds that often co-elute in HPLC. We are ready for challenges!
Fully integrated method development and solvent screening platform
Predicts, tests, and validates the most effective purification method of plenty of Compounds of Interest (CoI).
Support drug discovery
Compounds sourced from natural, chemistry, and biotechnological origins, navigating through complex matrices.
Large variety of solvent systems and orthogonality
Select between versatile purification and solvent systems to work with a wide range of CoIs.
Knowledge and expertise
Access a database based on 16,000 entries of scientific publications, solvent system examples, compound data and in-house research.
Mastering separations where conventional techniques fall short
CPC excels at resolving isomers, stereoisomers, and closely related compounds that often co-elute in HPLC.
