publications & research summaries
Explore scientific papers, conference posters, and research collaborations in which RotaChrom’s technologies played a key role. Below you will find the most recent publications featuring our CPC systems.
2026
Scientific Publication — Magyar kémiai folyóirat
Mate Vass, Noemi Crul-Toth, Attila Hunyadi, Anita Kiss, 2026 — A centrifugális megoszlási kromatográfia, mint skálázható és fenntartható technológia természetes és szintetikus vegyületek ipari tisztítására
This article presents Centrifugal Partition Chromatography (CPC) as a scalable and cost-effective liquid-liquid separation technique that uses centrifugal force to immobilize a liquid stationary phase, offering an efficient alternative to traditional solid-phase chromatography.
Scientific Publication — Separation and Purification Technology
Anita Kiss et al., 2026 — Scalable enantioseparation of rac-voriconazole by centrifugal partition chromatography: Process intensification leading to continuous operation
The study shows that cyclodextrin-based centrifugal partition chromatography (CPC) can be used as a scalable and more efficient continuous alternative to traditional batch resolution for producing highly pure (2R,3S)-voriconazole.
2025
Scientific Publication — Pharmaceutics
Daniela Hermosilha et al., 2025 — Valorization of Thyme Combined with Phytocannabinoids as Anti-Inflammatory Agents for Skin Diseases
This study highlights the potential of Thymus mastichina essential oil and its terpene-rich fractions, in combination with CBD and CBG, as promising topical agents for treating inflammatory skin diseases. The fractions were purified using Rotachrom rCPC chromatography.
Poster presentation — EUROCD
Anita Kiss, 2025 — Continuous chiral separation using cyclodextrin-containing liquid stationary phases (EuroCD 2025)
This study presents an innovative CPC method for the enantioselective separation of racemic voriconazole, achieving a 15-fold productivity increase and 99.9% purity using continuous MDM operation with cyclodextrin-based liquid stationary phases.
Poster presentation — GA2025
Maria Eduarda Soares Ramos et al., 2025 — Remediation of Pyrrolizidine Alkaloids in Plant Extracts (GA 2025)
This work demonstrates CPC’s effectiveness in removing toxic pyrrolizidine alkaloids from Red Clover extracts, achieving a tenfold reduction while preserving beneficial isoflavones, using RotaChrom’s Continuous CPC system.
Poster presentation — Flow Chemistry 2025
Reka Szabo, Anita Kiss, Dora Rutterschmid, 2025 — Chiral Separation of Voriconazole Using Continuous CPCA detailed poster presentation on the CPC purification of voriconazole — a challenging molecule that benefits greatly from continuous liquid-liquid separation to achieve high purity.
2022
Arpad Konczol, 2022 — Essentials of Centrifugal Partition Chromatography (Analytica Conference)
A summary of essential CPC principles, best practices and practical considerations, captured in a conference poster.
Melanie Gerigk et al., 2022 — Nonlinear liquid-liquid chromatography (Journal of Chromatography A)
Gergo Ignacz et al., 2022 — Sustainable Separations in Pharmaceutical Manufacturing (Book Chapter)
A review of sustainable downstream techniques in pharma, with special focus on eco-friendly separation technologies.
Arpad Konczol, Gergo Dargo, 2022 — Sustainable Features of CPC
Overview of the sustainability advantages of CPC compared to other separation methods, within the context of modern green engineering.
Bianka Varnai et al., 2022 — Sulfobutylation of Beta-Cyclodextrin Enhances Complex Formation with Mitragynine
A full spectroscopic characterization (NMR, CD) of the MTR–cyclodextrin interaction, including nonlinear LLC behavior evaluated for the first time.
Susanna Santos et al., 2022 — Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity
A study investigating bio-based CBD + terpene formulations for reducing viral entry and replication in SARS-CoV-2 models.
2021
Conference poster — American Oil Chemists’ Society
Arpad Konczol, Mario Nacsa, Eszter Blanar Petervarine, Erika Tamas Jantyikne, Dora Rutterschmid, Laszlo Ovari, Kristof Gazda, Gergo Dargo — 2021
Comprehensive Review on the Versatile Applications of Centrifugal Partition Chromatography in Cannabis and Hemp Processing
Conference poster summarizing how centrifugal partition chromatography can be applied across the cannabis and hemp value chain, from crude extract clean-up to targeted isolation of minor cannabinoids and terpenes.
Conference poster — METT25
David Laczko, Eszter Blanar Petervarine, Arpad Konczol, Attila Hunyadi — 2021
Ekdiszteroidok elválasztása méretnövelhető centrifugális megoszlásos kromatográfiával
Poster on scalable separation of ecdysteroids using centrifugal partition chromatography, demonstrating how CPC can be transferred from lab to preparative scale while preserving resolution and productivity.
Conference presentation — METT25
Arpad Konczol, Dora Rutterschmid, Gergo Dargo, Kristof Gazda, Laszlo Ovari, Mario Nacsa, David Laczko, Andras Gaspar — 2021
Research & Development of Centrifugal Partition Chromatography
An overview of RotaChrom’s R&D work in CPC, covering method development, scale-up strategies and technology innovations that enable continuous, industrial-scale liquid-liquid chromatography.
Conference presentation — Preparative and Process Chromatography
Gergo Dargo, David Laczko, Laszlo Ovari, Kristof Gazda, Mario Nacsa, Erika Jantyikne Tamas, Eszter Petervarine Blanar, Dora Rutterschmid, Laszlo Lorantfy, Arpad Konczol — 2021
Centrifugal Partition Chromatography at Industrial Scale: Concept, Instrumentation and Applications
Presentation detailing the design and performance of a fully integrated, industrial-scale CPC platform, including column architecture, solvent handling and key application examples.
2020
Article — Organic Process Research & Development
Laszlo Lorantfy, Dora Rutterschmid, Robert Orkenyi, David Bakonyi, Jozsef Farago, Gergo Dargo, Arpad Konczol — 2020
Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation
This paper describes the concept, control algorithm and hardware implementation of an automated solvent preparation and recycling system for continuous industrial-scale CPC, reducing solvent consumption and simplifying large-scale operation.
Conference presentation — American Chemical Society
Dora Rutterschmid, Arpad Konczol, Robert Orkenyi, Eszter Blanar, Erika Tamas, Laszlo Lorantfy, Kristof Gazda, Mario Nacsa, Laszlo Ovari — 2020
Centrifugal Partition Chromatography at Industrial-Scale: Concept, Instrumentation and Applications
ACS conference talk introducing a fully automated industrial-scale CPC platform with integrated biphasic system preparation and solvent recycling, illustrated through natural product applications such as cannabinoids.
Conference presentation — American Chemical Society
Robert Orkenyi, Laszlo Ovari, Kristof Gazda, Erika Tamas, Mario Nacsa, Eszter Blanar, Dora Rutterschmid, Laszlo Lorantfy, Andrea Boszormenyi, Balazs Kramos, Arpad Konczol — 2020
Cannabidiol Isolation Including Cannabis-Relevant Pesticides Removal by Centrifugal Partition Chromatography
A case study showing how CPC can be used to isolate high-purity cannabidiol while simultaneously removing cannabis-relevant pesticides, demonstrating the technology’s suitability for regulatory-compliant API production.