What Services Can RotaChrom Offer for CPC Purification?
Developing a reliable purification process requires more than selecting a chromatography technology.
RotaChrom provides CPC purification services covering the complete development journey from initial feasibility studies and CPC method development to process engineering, downstream processing integration, scale-up, training and ongoing technical support. Our objective is to help customers turn complex separation challenges into reliable, scalable Centrifugal Partition Chromatography processes.
But what exactly can RotaChrom do for your purification project?
CPC Feasibility Studies and Method Development
Every CPC process begins with understanding the target compound and the separation challenge. RotaChrom provides CPC feasibility studies and method development services designed to establish a clear, data-driven pathway toward high-purity, high-yield purification. Customers provide a representative sample, which is evaluated by our experts to identify the most suitable approach for the CPC process.
What Is Included in a RotaChrom CPC Feasibility Study?
Target Compound Examination
We evaluate key physicochemical properties such as polarity, solubility, stability, ionization behavior, and matrix composition. Understanding the impurity profile and the required purity, yield, and throughput is also essential for defining the development strategy.
Solvent System Screening
Our specialists select and evaluate suitable biphasic solvent systems and determine the partition coefficient (Kd) of the target compounds and relevant impurities. Solvent system selection is optimized according to the properties of the target compound and the required separation performance.
Laboratory-Scale Trials
Once promising conditions have been identified, laboratory CPC trials are performed to optimize key operating parameters such as flow rate, sample loading, retention time, and operating mode. Depending on the application, ascending, descending, or Multiple Dual-Mode (MDM) operation can be evaluated.
Process Optimization
The objective is to achieve the required balance between purity, yield, throughput, and solvent consumption. Experimental data generated during the feasibility study provides the foundation for developing a robust and scalable CPC purification method.
Scalability Assessment
Scalability is considered from the beginning of the development process. RotaChrom evaluates the most suitable production configuration and supports the transition from laboratory-scale development toward larger-scale purification through CPC scale-up or scale-out.
The result is more than simply a laboratory experiment. A RotaChrom feasibility study provides process data and a defined CPC purification strategy that can be used as the foundation for further process development and industrial implementation. This makes the service particularly valuable for companies that want to evaluate CPC before investing in equipment, optimize an existing purification challenge, or establish a clear route from laboratory research to scalable production.
Can the CPC Simulator Make Purification Method Development Faster?
RotaChrom also offers access to the CPC Simulator (https://rotachrom.com/cpc-simulator/), an in-house developed digital tool for purification method development. The CPC Simulator allows scientists to model purification performance before conducting extensive laboratory experiments. By using information such as partition coefficients and crude composition, users can evaluate solvent systems and simulate separation performance in silico. This can reduce the need for extensive shake-flask testing, HPLC measurements, and repeated CPC experiments, helping scientists make faster and more informed decisions during CPC process development.
Open to R&D Collaboration or CPC CRO Services?
Not every purification challenge can be solved using a standard development workflow. RotaChrom provides R&D collaboration and contract research services for organizations that require specialist expertise in liquid-liquid chromatography and CPC. As a specialized CPC CRO, RotaChrom can perform feasibility studies, method development, and purification testing on behalf of customers. Experimental work can be performed at RotaChrom facilities, generating CPC, HPLC, and HPLC-MS data where appropriate. This allows pharmaceutical, biotechnology, food, cosmetics and research organizations to access CPC expertise without having to establish the complete methodology and infrastructure internally.
Read more here: https://rotachrom.com/services-solution_planning_experimental_design/
Frequently Asked Questions
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What CPC purification services does RotaChrom provide?
RotaChrom provides CPC feasibility studies, method development, process optimization, CPC simulation, R&D collaboration, CRO services, process engineering, downstream processing integration, scale-up, training and technical support.
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Can RotaChrom develop a CPC purification method for my compound?
Yes. RotaChrom can perform feasibility studies and develop a tailor-made CPC purification method based on the compound, impurities, matrix, required purity, recovery, and process requirements.
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Can RotaChrom perform CPC purification development as a CRO?
Yes. RotaChrom offers CPC CRO and contract research services, allowing companies to outsource feasibility studies, method development, and purification experiments to a specialist CPC team.
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Can a laboratory CPC method be scaled to industrial production?
Yes. RotaChrom supports CPC scale-up from laboratory development toward pilot and industrial production, with process parameters and throughput considered during the scale-up process.
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When should I contact RotaChrom about a CPC purification project?
RotaChrom can be involved at different stages from an early feasibility assessment when you are unsure whether CPC is suitable, through method development, process optimization and scale-up. Early involvement can help determine the most appropriate purification strategy before significant development resources are committed.