Sustainable Purification of Amberketal: Centrifugal Partition Chromatography for Fragrance Industry Applications (Isomerism Part 3)
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RotaChrom
Industrial-scale Centrifugal Partition Chromatography
Pharmaceuticals / Natural Extracts / Food & Beverages / Cosmetics & Fragrances
Technologies
News
Amberketal, a synthetic equivalent of the highly valued natural ambergris, has gained prominence in the fragrance industry due to its rich woody aroma and its potential for sustainable…
Webinars
Continuous CPC Webinar With Arpad Konczol. Watch the Recording Now! RotaChrom’s Lead Scientific Officer Arpad Konczol recently did a webinar presentation detailing continuous chromatography, and how you can…
Events
RotaChrom Technologies was invited to a prestigious event organized by the Budapest HEPA Hungarian Export Promotion Agency, to take part in an event for building connections and showcasing…
What does RotaChrom do?
RotaChrom is a global leader in providing advanced chromatography solutions, offering expertise in purification and separation from early-stage research to industrial-scale operations. RotaChrom’s liquid-liquid-based centrifugal partition chromatography (CPC) technology is designed to eliminate the challenges associated with complex matrices and the technical issues of solid stationary phases. By employing straightforward liquid-liquid solvent systems, RotaChrom’s CPC technology also significantly reduces operational costs.
RotaChrom’s technology is renowned for its versatility, catering to a wide range of applications across various industries. This includes the purification of chemicals, life science products, natural extracts, specialty chemicals, and active pharmaceutical ingredients. The unique strengths of RotaChrom’s CPC technology consistently outperform traditional baseline methods, making it the preferred choice for efficient and cost-effective purification processes.
Industrial scale chromatography
Effortless scale-up from mg to kg/day to promote continuous production of APIs and macromolecules, and to improve treatments
Chromatography for the pharma environment
Proven GMP-compliant equipment design. Innovative, sustainable, and efficient industrial scale LC-CPC chromatography for the pharma industry
Versatile purification systems for a wide range of COIs
Natural compounds, alkaloids, macromolecules, chiral compounds, isomers, oligonucleotides, peptides, high or low-polar compounds, lipid nanoparticles, drug-like compounds, and biopolimers.
From research to industry
Select between lab-scale, pilot-scale, or industrial-scale purification
95% purity
Use CPC for isolation, separation, and remediation
20 kg/day
High production potential
Recover 95% of the solvent
Cost-effective
Without silica gel
No more expensive silica gel or resign are needed. Capitalize on innovative, sustainable, and efficient industrial scale liquid-liquid only CPC separation.
Environmentally friendly
CPC generates significantly less hazardous waste compared to traditional chromatography, since 95% of the solvents can be recycled and recirculated into the system.
Unparalleled Adaptability
The CPC infrastructure can be adapted for a new purification project within hours. Reach your desired combination of yield, purity and throughput in isolation, separation, or remediation.
About
chromatography
Centrifugal partition chromatography (CPC) is the process of purifying and separating components from crude mixtures. A target compound may have ingredients that are useful, beneficial and are highly valuable for compound development or commercially sold products, while others must be extracted through a delicate and thorough purification process.
RotaChrom’s proven GMP-compliant CPC equipment design is highly involved in the downstream processing of natural extracts, foods, beverages, fragrances, fine chemicals, and pharmaceuticals. CPC instruments designed from the benchtop to continuous manufacturing and industrial-scale operation offer flexible resolving power, so you can reach your desired combination of yield, purity, and throughput in isolation, separation, or remediation.
RotaChrom Products
CPC Modeler
The CPC Modeler is a compact CPC platform that integrates an intuitive method development engine with custom semi-preparative chromatographic equipment. It predicts, tests, and validates optimal purification methods for various compounds, allowing for scalable production. With a loading capacity from mg to g per cycle, it can purify pharmaceutical APIs, natural extracts, and other compounds handled by the rCPC.
rCPC
The rCPC platform is designed to execute pilot scale purification tasks within a laboratory environment, making it ideal for any batch, smaller or larger, or campaign type of research work as well as continuous batch production. Test your product before rolling them out to the market.
GMP rCPC
The GMP rCPC is designed to adhere to cGMP regulations according to Eudralex Vol. 4. The platform can be used for API-grade compound production and pilot-scale purification and research tasks in a pharmaceutical environment. It is possible to collect up to 9 COI fractions and 1 Impurity fraction.
Continuous CPC
The Continuous CPC platform is a continuous, multiple dual-mode, dual-rotor CPC platform. It consists of two interconnected GMP-rCPC devices, a preparative unit, and the control unit. Unlike the standard batch operational mode, it enhances throughput with its continuous injection mode, allowing for more efficient sample processing and multiple increase in production, beside low operational cost.
iCPC
The iCPC is the largest serialized centrifugal partition chromatographic platform in the world, designed for industrial scale purification projects in continuous batch operation mode, with the capacity to process hundreds of kilograms per month of crude input material. Bid farewell to silica, and linear scale-up your production to kg/day with flexible, affordable, robust, future-proof chromatography.
pCPC
This tailor-made system pCPC by RotaChrom is a combination of iCPC and solvent preparation and recovery, and regeneration. It also delivers a proprietary automated biphasic solvent system preparation platform, providing a flexible and continuous feed to our iCPC instrument. Automate your complete purification process and make products that meet all standards.
RotaChrom Services
Feasibility study
A study run by RotaChrom’s laboratory with the Partner’s material to evaluate the possible outcomes and to prove the successful purification of the target compound by RotaChrom CPC technology.
Method development and optimization
Tailor-made methods are being developed and adapted on RotaChrom CPC systems for the individual matrices and compounds of interest, derived from our Clients.
Optional production scale pilot study
After a feasibility study in certain cases it is a recommended option to conduct a production scale pilot study with RotaChrom’s expert team to optimize future operational parameters and enhance potential yield and profit.
Factory design consultancy
Joint efforts with Clients to find the most effective and viable layout and factory setup. RotaChrom prior installation, details installation requirements and recommends optimal layout for the individual processes of the Client, while local safety specifications and regulatory requirements are applied and defined beforehand by the Client.
Maintenance service agreement
Regular preventive maintenance to ensure safe and reliable operation.
Contact Us
RotaChrom Technologies LLC | Industrial-scale Chromatography