TECHNOLOGY
Technical integration
From concept to reality: we engineer every step of purification transition.
For engineers, CPC offers a practical purification technology that is not only effective, but also robust, compliant, scalable, and easy to integrate. Whether you’re optimizing an existing workflow or designing a new downstream process, Centrifugal Partition Chromatography can be seamlessly integrated at multiple stages of the purification chain.
It enables straightforward tech transfer from R&D to manufacturing, minimizing the need for method redesign and reducing overall process complexity. It also supports compliance in regulated environments by offering system configurations and documentation aligned with international industrial standards.
CPC in Downstream Purification Workflow: Tailored integration with other purification methods
For engineers, CPC offers a practical purification technology that is not only effective, but also robust, compliant, scalable, and easy to integrate. Whether you’re optimizing an existing workflow or designing a new downstream process, Centrifugal Partition Chromatography can be seamlessly integrated at multiple stages of the purification chain. It enables straightforward tech transfer from R&D to manufacturing, minimizing the need for method redesign and reducing overall process complexity. It also supports compliance in regulated environments by offering system configurations and documentation aligned with international industrial standards.
Filtration
Extraction,
Phase exchange
Solvent exchange
Crystallization/
Drying →
Formulation
Clarification
Concentration,
Solvent exchange
Crystallization/
Drying →
Formulation
pH adjustment
pH adjustment,
solvent exchange
Crystallization/
Drying →
Formulation
Filtration
destillation →
Polishing → Drying
→ Formulation
Process Engineering and System Integration:
How a CPC Purification Process and a CPC system Is Designed – From Lab Method to Full-Scale Operation
How a CPC Purification Process and a CPC system Is Designed – From Lab Method to Full-Scale Operation
CPC purification begins with method development tailored to the client’s goals. After successful lab-scale testing, engineers define the full system layout in a preliminary Process Flow Diagram (PFD), outlining equipment, flow paths, and all supporting components. This setup is then validated and optimized through simulation using Process Flow Calculator (PFC), which ensures performance, identifies bottlenecks, and confirms scalability. Once the configuration is finalized, a detailed Process and Instrumentation Diagram (P&ID) is created to guide implementation and future operation. This systematic approach ensures that the process is optimized for the client’s specific needs, while also leaving room for future expansions or changes to the system.
User Requirements
Specification (URS)
Chromatography
method development
Standard Process Flow
Diagrams (PFD)
Process and Instrumentation
Diagram (P&ID)
Optimized, final
PFD
Process Flow
Calculator (PFC)
Tech transfer and scale-up: Scalability with CPC: CPC technology and increased throughput
The CPC technology offers multiple approaches to increase throughput, either via the classical volumetric scale-up or, when traditional scale-up is not working, a scale-out. CPC platforms offer linear scalability from benchtop-scale to industrial-scale. By investing in CPC technology, businesses can streamline their processes by using a single solution for method/process development and production, reducing the need for multiple technologies.
Compliance & Validation
With the growing demand for high-purity compounds in pharmaceuticals, natural products, and nutraceuticals, CPC is gaining traction as a reliable, scalable, and cost-efficient separation method. Each CPC system can be configured with the required certifications and markings to meet international industrial standards, ensuring smooth integration into regulated environments. CPC systems are fully modular and customizable, with optional certifications based on client-specific demands.
