Separation of Remdesivir Diastereomeres by Centrifugal Partition Chromatography

Continuous CPC Webinar With Arpad Konczol. Watch the Recording Now!

RotaChrom’s Lead Scientific Officer Arpad Konczol recently did a webinar presentation detailing continuous chromatography, and how you can apply said technology for maximum purification benefits.

Exploring Remdesivir Separation: A Glimpse into the Future

Continuous Centrifugal Partition Chromatography (CPC) is a game-changer in the world of chromatography. This innovative technique brings unparalleled efficiency and productivity to the table, transforming how we approach separations in various industries, even in ones that already use tried-and-tested batch separation processes. Arpad Konczol, RotaChrom’s lead scientific officer, provided in-depth insights into this cutting-edge technology was used for Remdesivir separation during the webinar.

Continuous CPC, In a Nutshell

If you’re unsure whether this webinar is for you, here is a short recap about what is continuous purification.

In traditional batch processes, the production of a specific quantity of the desired product occurs within a single production run, marked by a clear start and endpoint. Once the batch is finished, a new production cycle can commence.

On the contrary, continuous processes operate seamlessly without defined start or endpoint markers. They are engineered to maintain uninterrupted and ongoing production of the product, resulting in a continuous inflow of raw materials and a consistent outflow of the product.

Continuous processing particularly shines in scenarios requiring large-scale production of a single product, fitting perfectly into high-demand settings. It also integrates seamlessly with various other continuous technologies.

In the modern landscape, centrifugal partition chromatography (CPC) separations have evolved significantly, now constituting routine work at laboratory scale. The complexity of selecting suitable solvent systems has been simplified thanks to the availability of comprehensive sets of solvent combinations detailed in numerous publications and books.

Responding to this advancement, the innovation of Multiple Dual-Mode (MDM) CPC has emerged as a user-friendly alternative technique. An MDM separation involves a series of dual-mode runs, wherein the stationary and mobile phases are inverted multiple times.

What Was Covered?

• Continuous CPC Demystified: Gain a comprehensive understanding of the principles and mechanisms behind continuous CPC. Discover how it differs from traditional batch-processing methods and why it’s a breakthrough in the field.
• Uses and Benefits: Explore the diverse applications and the immense potential of continuous CPC. See how the technology was used in separating Remdesivir.
• Success Stories: Árpád Könczöl shared a success story and case study, which involved a very difficult separation challenge of Remdesivir which his team managed to overcome with continuous CPC. The study showcases how continuous CPC has empowered labs to achieve remarkable outcomes. It is a real-world example demonstrating the transformative impact of this technology.

How to Access the Recording

We understand that schedules can be demanding, and sometimes attending live events isn’t feasible. That’s why we’ve made the recording of this insightful webinar available for you to watch at your convenience.

To access the recording and immerse yourself in the world of continuous CPC, simply click here to view the webinar.