• RotaChrom CPC Instruments & Solutions
  • Technology
  • About Us
  • FAQ
  • Blog
  • Webinars
  • Podcasts
  • Pressroom
  • Contact
Here you can see the logo of RotaChrom Technologies.
Here you can see the logo of RotaChrom Technologies.
  • Products
    • CPC Modeler
    • GMP rCPC
    • rCPC
    • iCPC
    • Continuous CPC
    • pCPC
    • SKIDS
  • Pricing
  • Technology
  • Applications
    • Pharma and biotech
    • Cosmetics and Fragrances
    • Food and Beverages
    • Botanical applications
  • Calculator
  • Company
    • About Us
    • Events
  • Resources
    • Blog
    • Webinars
    • Publications
    • Pressroom
    • FAQ
    • Podcasts
  • Contact
    • Career
    • Contact
    • Book a meeting

Optimizing Solvent Consumption For Your Chromatographic Solution

February 11, 2024
In News
Share via Share via Share via Share via

Centrifugal Partition Chromatography (CPC) is emerging as a sustainable alternative to traditional chromatography methods, offering solutions to address environmental concerns. Let’s delve into the reasons why traditional chromatography is deemed unsustainable and how CPC presents a greener approach.

High Solvent Consumption in Traditional Chromatography: Traditional methods often rely on solid supports like silica gel columns, necessitating large amounts of solvents for elution.

  • Environmental Impact: Excessive solvent usage raises environmental and economic concerns, particularly with hazardous organic solvents that may require energy-intensive recovery or disposal methods.
  • Waste Generation from Solid Supports: The use of packed columns with materials like silica gel leads to the generation of solid waste.
  • Environmental Challenges: Disposing of spent solid supports poses challenges in waste management and contributes to environmental impact.
  • Limited Range of Available Solvents: Traditional chromatography typically operates with a restricted set of solvents compatible with solid supports like silica gel.
  • Restrictions on Optimization: This limitation hampers optimization for specific separations, constraining the choice of solvent systems.

In contrast, CPC offers a sustainable alternative by operating as a liquid-liquid chromatography technique, eliminating the need for solid supports like silica gel. This fundamental distinction significantly reduces solvent consumption and minimizes solid waste associated with packed columns, thereby aligning with sustainability objectives. Furthermore, CPC provides a broader range of available solvents, including greener and more sustainable options, further enhancing its environmental profile.

Efficient solvent recycling is integral to sustainable chromatographic separations, with techniques like membrane filtration, dialysis, ultrafiltration, and density-based recirculation showcasing significant potential:

  • Membrane Filtration: Combining countercurrent chromatography with organic solvent nanofiltration (OSN) has proven cost-effective for purifying APIs, achieving high efficiency and highlighting the importance of optimizing CCC mass-efficiency.
  • Dialysis: Implemented to isolate separated compounds and recycle phases, dialysis shows promise in reducing the carbon footprint compared to CPC runs without dialysis.
  • Ultrafiltration: This technique demonstrates substantial solvent recovery results in CPC processes, enabling high recovery rates and purity before recycling solvents, thereby reducing the carbon footprint.
  • Density-Based Recirculation: Investigating continuous in-line solvent recycling and readjustment based on density measurements, this method enhances CPC cycles and yields high-purity products while recovering solvents for reuse.

Overall, these studies underscore the potential of recycling techniques to enhance the sustainability of CPC processes by reducing solvent consumption, minimizing waste generation, and maximizing solvent reuse, thereby contributing to greener and more efficient chromatographic separations.

Previous article
Liquid-Liquid Chromatography's Role in the Nonlinear Range
Next article
Unveiling the Power of Centrifugal Partition Chromatography

Related News

Other posts that you should not miss.
CPhI Worldwide in Madrid - RotaChrom booth

RotaChrom at CPhI Worldwide

October 25, 2018
-
Exhibitions, News
CPhI Worldwide together with co-located events ICSE, InnoPack, P-MEC and FDF, hosted more than 45,000 visiting pharma professionals over three days in October 2018.
Read More →
1 MIN READ
HPLC Milan logo

Great recognition at HPLC

June 21, 2019
-
Exhibitions, News
RotaChrom’s unique purification technique earned a great recognition at HPLC 2019
Read More →
1 MIN READ
GMP header

What is Good Manufacturing Practice (GMP)?

April 10, 2023
-
Education, News
DOWNLOAD YOUR FREE GUIDE FOR cGMP-COMPLIANCE. Click here and download your brochure containing even more in-depth knowledge about cGMP compliance and learning how you can update your current…
Read More →
3 MIN READ

Latest News

Increasing separation efficiency by pH adjustment in Centrifugal Partition Chromatography

May 19, 2025 – News

Addressing pH Issues in Chromatography: From Solid-Phase to Liquid-Liquid Separations

May 15, 2025 – Education, News

Chemspec 2025

May 15, 2025 – Conferences, Education, Exhibitions, News

Advancing Separation Science: CPC Device Installation and Its Impact

April 17, 2025 – News

Webinars

Separation of Remdesivir Diastereomeres by Centrifugal Partition Chromatography

September 25, 2023

Green Features of Centrifugal Partition Chromatography

May 10, 2021

Contact Us

RotaChrom Technologies PLC (Headquarters)

Csillag street 2/A, Kecskemet, HU-6000

+36 70 885 6922

RotaChrom North America Inc.

300 Spectrum Center Drive, Irvine, CA 92618

+1 (720) 220-5669

Cookie Policy  /  Data Protection Policy  /  RotaChrom® is a registered trademark of Rotachrom Technologies in the USA and EU. / © 2025 RotaChrom Technologies. All rights reserved.
Optimizing Solvent Consumption For Your Chromatographic Solution - Rotachrom Technologies