brochures and whitepapers
CPC Modeler
What do you find in this brochure?
- CPC-based method development from laboratory to industrial scale
- In silico solvent system selection with the CPC Simulator
- Benchtop CPC validation for rapid method testing and optimization
- Predictable scale-up across the RotaChrom CPC platform ecosystem
- Cost-efficient, silica-free purification for diverse compounds of interest
GMP-rCPC
What do you find in this brochure?
- GMP-compliant CPC platform for pilot-scale and API-grade purification
- Design, qualification, and validation according to pharma regulations
- Integrated cleaning validation, material traceability, and audit readiness
- Flexible at-line and pilot-scale purification for pharmaceutical workflows
- Proven application examples across APIs, peptides, and proteins
Continuous CPC
What do you find in this brochure?
- Principles and benefits of continuous purification with CPC
- Multiple dual-mode (MDM) CPC for enhanced resolution and productivity
- Comparison of batch vs. continuous chromatographic processing
- Industrial-scale Continuous CPC system design and automation
- Real case studies demonstrating increased throughput and reduced OPEX
iCPC with solvent preparation and recycling system
What do you find in this brochure?
- Industrial-scale iCPC platform with integrated solvent management
- Sustainable purification with solvent recovery and reduced OPEX
- Scalable method development from lab to 23 L industrial rotor
- High-purity isolation with high loading capacity and throughput
- GMP-, CE-, and UL-compliant design for regulated environments
Regulatory and standards compliance guide for cpc systems
What do you find in this white paper?
- Overview of regulatory and compliance requirements for CPC systems
- CE, UL/NRTL, ATEX, and IECEx certification pathways explained
- GMP-compliant design, qualification, and validation workflows
- Customizable CPC equipment aligned with regional regulations
- Cleaning validation and documentation for audit-ready operation
Full-scale system suitability and reliability assessment
What do you find in this application note?
- CPC system suitability assessment using paraben model compounds
- Resolution, stationary phase retention, and load optimization strategies
- Impact of centrifugal force on separation performance and robustness
- Linear scalability from benchtop to pilot-scale CPC systems
- Benchmarking CPC reliability for pharmaceutical and process applications
Isomer separation
What do you find in this application note?
- Fundamentals of isomerism and industrial separation challenges
- Comparison of chiral separation technologies and their limitations
- How CPC enables scalable, cost-effective isomer purification
- Real-world case studies across pharma, flavors, and specialty chemicals
- Strategies for transitioning isomer separation from lab to industrial scale
Natural extract separation
What do you find in this application note?
- How CPC enables cost-effective purification of complex natural extracts
- Practical strategies for isolation, remediation, and fractionation
- Real-world case studies across nutraceutical, pharmaceutical, and cannabinoid applications
- Methods for improving yield, scalability, and process robustness
- Guidance on solvent selection, cost efficiency, and waste valorization
High-purity curcuminoid purification
What do you find in this application note?
- Two-stage CPC strategy for high-purity curcuminoid purification
- Bulk matrix removal using elution mode CPC
- Individual curcuminoid isolation with pH-zone refining
- Scalable purification from pilot to industrial production
- High recovery and cost-efficient processing without solid stationary phases
Separation of oligonucleotides
What do you find in this brochure?
- Use of IEX-CPC for scalable oligonucleotide purification
- Solvent-system design for selective separation and endotoxin removal
- Single-step purification achieving high purity and yield
- Practical case study with a 20-mer oligonucleotide sample
- Cost-effective alternative to resin-based chromatography
LNP purification
What do you find in this application note?
- How CPC enables efficient purification of different lipid classes
- Ways to minimize degradation while improving process robustness
- Case studies demonstrating the purification of key LNP components: DMG-PEG 2000, ALC-0315, 19B28, and 23B1
- Compare CPC with traditional purification techniques
- Learn about scalable purification strategies for industrial lipid manufacturing
Principles of liquid-liquid chromatography
What do you find in this white paper?
- The role of chromatography within the downstream process chain
- Fundamental principles of chromatographic separation
- Differences between liquid–solid and liquid–liquid chromatography
- How to read chromatograms and optimize fraction collection
- The basics of Centrifugal Partition Chromatography and its advantages
Advanced chromatography
What do you find in this white paper?
- Advanced principles of liquid–liquid chromatography and CPC
- How partition coefficients and resolution determine separation performance
- CPC operating modes, cell design, and scalability considerations
- Strategies for isolation, separation, and remediation of complex mixtures
- Real application examples from pharmaceutical and biochemical purification
Exploring how CPC progresses green chemistry practices
What do you find in this white paper?
- Why conventional preparative chromatography is environmentally unsustainable
- CPC as a green alternative to solid-based separation techniques
- Strategies for solvent selection, recycling, and circular solvent use
- Integration of CPC into downstream processes and bioreactor systems
- Waste valorization examples enabled by CPC-based purification
Quick Reference guide
What do you find in this guide?
- Overview of centrifugal partition chromatography and how it works.
- Diagrams showing the workflow and the main parts of the equipment.
- Different solvent systems, polarity maps, and miscibility tables.
- Formulas and charts related to partition coefficients, retention, and efficiency.
- Practical guidelines for choosing solvents and optimizing separation.
