Increasing separation efficiency by pH adjustment in Centrifugal Partition Chromatography
NewsIn the realm of chromatography, RotaChrom’s Continuous Centrifugal Partition Chromatography (Continuous CPC) platform represents a groundbreaking leap into the future. This revolutionary technology goes beyond traditional batch processes, introducing a continuous and highly efficient method for separation and purification. In this article, we’ll explore the intricacies of this innovative advancement and its transformative impact on chromatographic techniques.
Continuous CPC Platform Overview
The Continuous CPC platform is an engineering marvel, featuring two interconnected GMP-rCPC devices—a preparative unit and a control unit. Its dual-mode, dual-rotor design sets it apart, allowing for continuous injection mode and significantly boosting throughput and efficiency. This continuous processing method ensures uninterrupted sample processing, meeting the dynamic demands of modern industry.
Scalability and Adaptability
What distinguishes the Continuous CPC is its scalability and adaptability to various sizes and industrial requirements. Compliant with Good Manufacturing Practice (GMP) standards, this robust platform offers consistent performance in demanding industrial settings. Its versatility shines through in its ability to handle liquid-liquid chromatography, providing a flexible solution for diverse separation needs.
On-Demand Solvent Handling System
A standout feature of the Continuous CPC is its on-demand solvent handling system, customizable to specific industrial standards. This not only simplifies chromatographic operations but also optimizes solvent usage, aligning with sustainability goals and reducing environmental impact.
Continuous Production Benefits
The transition from batch to continuous processing marks a significant stride in chromatography. Continuous manufacturing offers several benefits, including:
Facilitating a smooth transition to higher production volumes by eliminating batch-related constraints.
Minimizing both capital and operational expenditures.
Reducing waste, improving resource utilization, and enabling effective solvent recycling due to the absence of frequent start-ups and shutdowns.
Automation and Efficiency
Automation plays a pivotal role in enhancing efficiency and reducing human errors in continuous manufacturing. Predictive maintenance techniques optimize equipment lifespan and prevent downtime, ensuring a seamless production flow. Additionally, the considerably smaller footprint of continuous manufacturing equipment optimizes space utilization within facilities.
Continuous CPC Operation
The Continuous CPC platform operates with a dynamic system featuring two connected rotors and four pumps, enabling continuous or semi-continuous operation. Each cycle involves two steps resembling the ascending and descending elution steps in traditional CPC separation modes. This design aligns with high-throughput separation technologies like Simulated Moving Bed (SMB), making it a powerful tool for continuous separation of binary mixtures.
GMP-Compliant Standards
RotaChrom’s Continuous CPC platform adheres to GMP-compliant standards, ensuring durability and reliability. Key features include:
Explosion-proof design suitable for installation in ATEX/IECEx Zone 2 environments.
Pre-certified electrical cabinet for added safety assurance.
Wetted components constructed from high-quality materials like 316L/1.4404 stainless steel or PEEK for maximum durability and reliability.
Compliance with cleaning validation and cleaning standards in line with GMP directives.
Conclusion
RotaChrom’s Continuous CPC platform is a testament to innovation in chromatography, promising a future where continuous manufacturing seamlessly integrates with chromatographic techniques. With its scalability, adaptability, and adherence to GMP standards, this platform is reshaping the landscape of chromatographic processes, advancing industries and catalyzing progress.