RotaChrom CPC
Instruments & Solutions

Main CPC technology platforms:
the rCPC and the iCPC

RotaChrom offers a wide range of solutions to meet your business needs and help you boost your performance. Our one-of-a-kind CPC technology is at the heart of our devices, which we use in both the rCPC and iCPC platforms.

On the other hand, we understand that specific tasks often require specific tools. This is why we support our partners with flexible prices and tailor-made configurations based on unique input provided by the business partner. Add-ons for the rCPC and iCPC devices are available, whether you need solvent handling, or polishing a final product, just to name a few applications. RotaChrom’s unique devices are ready to tackle any challenge they face.

Here you can see a RotaChrom rCPC.

rCPC

Our engineers designed the rCPC platform for pilot-scale purification tasks within a laboratory environment. It is ideal for all batch sizes, smaller or larger, or campaign type of research work, and continuous-batch production. To accommodate a user-friendly operation, RotaChrom offers a turn-key solution package for semi-automated solvent handling (preparation and recovery) upon request.

Furthermore, rCPC can be utilized as an at-line purification platform besides our industrial-scale purification unit. This means your separation needs can be executed in an orthogonal manner. A category of its own, the rCPC offers outstanding throughput, purity and yield, and does all that while remaining cost-efficiency.

Going beyond the general requirements, RotaChrom offers tailor-made system modifications, and does it while fulfilling any regulatory requirements you have to meet.

Pricing is based on the extent of the unique configuration and specific expectations. Contact us today to learn more.

Here you can see an iCPC instrument.

iCPC

RotaChrom’s iCPC platform is the largest commercially available Centrifugal Partition Chromatography instrument in the world. Designed for industrial-scale purification projects in continuous batch operation mode, this device is by far the most cost-effective industrial-scale chromatography platform available on the market. It has the capacity to process hundreds of kilograms of crude input material per month.

The iCPC uses similar technical features as our pilot-scale system, the rCPC. Nonetheless, it maintains the same relative load and resolution capabilities. Furthermore, the iCPC is designed to operate in an industrial environment. It is controlled by a PLC (Programmable Logic Controller) unit, which enables system finetuning and the aligned functioning of multiple devices.

Upon request, the iCPC can be operated as a standalone instrument as well as in clusters, or extended with a fully integrated solvent handling system.

Pricing is based on the extent of the unique configuration and specific expectations. Contact us today to learn more.

Custom-made solutions

Here you can see a pCPC instrument.

pCPC

The pCPC is a tailor-made system by RotaChrom. It is a combination of the iCPC and a solvent preparation, recovery and regeneration system. It also delivers a proprietary automated biphasic solvent system preparation platform, providing a continuous feed to our iCPC instrument.

pCPC encompasses a fully integrated production platform where complete solvent handling is provided beside the iCPC’s purification solutions. The system is controlled by PLC, and can be operated in a hazardous environment in compliance with existing regulatory requirements.

The scaled-up and extended system provides a versatile solution. The integrated solvent regeneration platform significantly reduces the cost of operation. Thanks to RotaChrom’s customer support and prediction tools, the operational cost, process flow and layout can be tailored to customer needs before installation.

Here you can see a pCPC plus COI instrument.

pCPC + HeiVap platform

Add even more to your production with pCPC combined with the Heivap platform. This is a complex solution which enables complete solvent handling and allows the elimination of solvents and final polish of the product. The strategic partnership RotaChrom entered into with Heidolph comes with the possibility to combine the pCPC with Heidolph Heivap platform.

The scaled-up and extended system provides a versatile solution, while the integrated solvent regeneration platform reduces the costs of operation. Thanks to RotaChrom’s customer support and prediction tools, the operational cost, process flow and layout can be tailored to your needs before installation.

RotaChrom CPC Device Overview

  • Technical features ¹rCPCiCPC
  • Loading capacityup to 150 g/cycleup to 1200 g/cycle
  • Average flow rate~250 mL/min~2500 mL/min
  • Throughput ²2 kg/day20 kg/day
  • Weight470 kg / 1036 lbs1600 kg / 3527 lbs
  • Dimensions ³3'3” x 4'3” x 3'5”4'11” x 5'11” x 4'9”

¹ Industry relevant certifications (i.e. ATEX, UL, CSA) are available upon request for pCPC platform and subjected to individual design reviews, based on the operational environment.

² Amount of the crude/input material and based on 2 shifts (16h)/day operation scheme.

³ Total footprint of the complete system, including SKID platforms,  may vary due to the individual Client location. For further details please refer to FAQ and contact RotaChrom directly.

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Why invest in a RotaChrom CPC platform?

Through the platforms RotaChrom offers, manufacturers have no limits on adapting the system for new downstream challenges from small molecule APIs to macromolecules or from hydrophobic lipids to completely hydrophilic peptides all with the same machine.

Zero Silica Gel in
the Purification Process

RotaChrom’s CPC platform does not need any solid stationary phase (like silica gel) to achieve efficient industrial scale separation.

High Resolution
Performance

The CPC platform is demonstrably superior to preparative HPLC, SMB, Ion exchange, Flash chromatography, crystallization, as well as chiral chromatography in terms of purity, yield, and return on investment.

Adaptability
and Scale-Up

The CPC system has almost no limits on adaptation from small molecule APIs to macromolecules or from hydrophobic lipids to completely hydrophilic peptides on the same instrument.

Exceptional Quality

RotaChrom’s staff is skilled in quality assurance, risk management, good validation and qualification practice, to apply and implement standard operation procedures in a client working environment.

Core advantages

  • Conventional industrial LC*RotaChrom industrial CPC
  • High solvent consumptionLess solvent consumption
  • Expensive stationary phase; difficult column fillingNo solid bulk material; Solvents with higher impurities can be utilized
  • Only the mobile phase is recyclable Both phases are >95% recyclable (organic solvents)
  • Irreversible adsorption and denaturation Irreversible adsorption not possible
  • Difficult scale-up – complete redesign needed Easy scale up from grams/batch to tons/month production in weeks
  • Limited adaptation for different application (major change of instrument needed for different application) Almost no limits on adaptation from small molecule APIs to macromolecules from extremely hydrophobic lipids to completely hydrophilic peptides
  • Yield limited due to multi-step processes Allows much fewer steps resulting in much higher yields and technical grade solvents can also be used
  • Long retention time and lower productivityShorter retention times through customized solvent system composition which results higher productivity

* Liquid chromatography

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Fill the details below and learn about RotaChrom’s CPC technology tailored to your interests.

Working process with RotaChrom

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Case Study – Mutual Assessment of Collaboration

Based on the scientific and financial specifications of a given purification project and the detailed requirements, RotaChrom’s CPC professionals analyze the project’s feasibility in a Case Study to determine the most cost effective and efficient solution RotaChrom’s CPC technology can offer. RotaChrom closely works together with its partner to achieve the most beneficial solution for long-term success.

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Optional Feasibility Study

For some applications we recommended conducting a Feasibility Study. With the help of RotaChrom’s chemists, you can achieve top performance of your CPC platform. In a feasibility study, our experts screens various solvent systems to find the biphasic system most suitable for a partner’s expectations in a purification project. The results are provided to the partner in the form of a Study Report and the purified material is returned for verification. If requested, the Feasibility Study can be extended to examine purification and isolation of further compounds from the sample or to various solvent recovery modules for the highest cost efficiency.

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Installation and Training

RotaChrom will help its partners select the appropriate scale of CPC platform that meets their standards. After the delivery, RotaChrom’s qualified engineering team installs the CPC device according to the site’s acceptance test protocol and trains the partner’s staff to use the instrument efficiently and independently.

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Customer Technical Support – at Your Service Anytime!

RotaChrom’s professional and devoted colleagues at the Customer Technical Support Department are a phone call away to provide the quickest and highest quality services. All RotaChrom partners receive Installation & Maintenance Manuals, Product Datasheets and Site Requirement documents. We also offer Preventative maintenance schedules and a list of wearing parts to minimize down-time and maximize the instrument’s reliability. RotaChrom’s Service & Maintenance professionals are ready to eliminate all technical obstacles from the way of lucrative business worldwide.

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On-Site Consultancy: New Method or Scale-Up Development

If the Partners require additional professional guidance, RotaChrom’s Technical Support Team provides high-standard consultancy services around the world. Whether it’s new method or scale-up development, RotaChrom’s trained and experienced Technical Support Representatives are at your service on-site.

Let's begin the cooperation!

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RotaChrom's Chromatography Products | RotaChrom Technologies LLC.