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RotaChrom CPC
Instruments & Solutions

RotaChrom offers three CPC technology platforms for purchase:
the rCPC, iCPC, and pCPC.
RotaChrom rCPC platform - product picture

rCPC

High resolution pilot scale centrifugal partition chromatographic platform which is ideal for method development as well as for pilot scale purification. With this platform, manufacturers have no limits in adapting the system for new downstream challenges from small molecule APIs to macromolecules or from hydrophobic lipids to hydrophilic peptides all on the same machine.

RotaChrom iCPC platform - product picture

iCPC

The largest centrifugal partition chromatographic instrument in the world. RotaChrom is the sole manufacturer and distributor of the industrial scale CPC instrument and provides various products and services facilitating downstream silica gel free preparative industrial scale production. Buying an iCPC device provides many technical and economical advantages to your current and future downstream method development.

pCPC instrument - product picture

pCPC

The pCPC unit is comprised of the RotaChrom iCPC instrument and a SKID system which optimizes industrial scale solvent preparation, recycling, recovery and recirculation. This platform is capable of performing continuous batch production, processing up to 20 kg of input material per day.

pCPC+ COI - product picture

pCPC + COI

The pCPC unit is comprised of the RotaChrom iCPC instrument and a SKID system which optimizes industrial scale solvent preparation, recycling, recovery and recirculation. This platform is capable of performing continuous batch production, processing up to 20 kg of input material per day.

RotaChrom CPC Device Overview

  • Technical featuresrCPCiCPC
  • Loading Capacityup to 75 gup to 750 g
  • Average Flow Rate250 mL/min 2.5 L/min
  • Processing Capacityup to 2kg/dayup to 20 kg/day
  • Weight470 kg / 1036 lbs1.6 t / 3527 lbs
  • Dimensions

    3'3” x 4'3” x 3'5”4'11” x 5'11” x 4'9”

Why invest in
a RotaChrom CPC platform?

Through the platforms RotaChrom offers, manufacturers have no limits on adapting the system for new downstream challenges from small molecule APIs to macromolecules or from hydrophobic lipids to completely hydrophilic peptides all on the same machine.

Zero Silica Gel in
the Purification Process

RotaChrom iCPC platform does not utilize any solid stationary phase, like normal phase or reversed phase silica, in order to achieve efficient industrial scale mixture separation.

High Resolution
Performance

The iCPC platform has been proven superior to preparative HPLC, SMB, Ion exchange, Flash chromatography, crystallization, as well as chiral chromatography in terms of purity, yield, and return on investment.

Adaptability
and scale-up

The iCPC system has almost no limits on adaptation from small molecule APIs to macromolecules or from hydrophobic lipids to completely hydrophilic peptides on the same instrument.

Exceptional
quality

RotaChrom staff is well-skilled in quality assurance, risk management, Good Validation and Qualification Practice in order to apply and implement standard GMP methodology within technology transfer and commissioning.

Core advantages

  • Conventional industrial LCRotaChrom industrial CPC
  • High solvent consumption

    Less solvent consumption

  • Expensive stationary phase; difficult column fillingNo solid bulk material
  • Only the mobile phase is recyclable Both phases are >95% recyclable
  • Irreversible adsorption denaturation No irreversibility detected
  • Difficult scale-up – complete redesign needed
    that takes years
    Easy scale up from grams/batch to tons/month production in weeks
  • Limited adaption for different application

    (major change of instrument needed
    for different application)

    Almost no limits on adaption from small molecule APIs to macromolecules from extremely hydrophobic lipids to completely hydrophilic peptides
  • Yield limited due to multi-step processes Allows for much fewer steps which means much higher yield and Technical Grade Solvents can be used
  • Long retention time and lower productivityShorter retention times through customized solvent system composition which results higher productivity

Working process with RotaChrom

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Case Study – Mutual Assessment of Collaboration

Based on the scientific and financial specifications of a given purification project and the detailed requirements, RotaChrom CPC professionals analyze the project’s feasibility in a Case Study to determine the most cost effective and efficient solution RotaChrom CPC technology can offer. Rotachrom works together with its Partner closely in order to achieve the most beneficial solution for a long-term success.

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Optional Feasibility Study

For certain applications it is highly recommended conducting a Feasibility Study with  RotaChrom’s expert chemists to bring out the best performance of the CPC platform. During the study, RotaChrom screens various solvent systems to determine a biphasic system which is the most suitable and meets the Partner’s expectations for a given purification project. The results are provided to the Partner in the form of a Study Report and the purified material is returned for verification. If requested, the Feasibility Study can be extended to examine purification and isolation of further compounds from the sample or to various solvent recovery modules for the highest cost efficiency.

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Installation and Training

RotaChrom’s professionals can help its esteemed Partners to choose the most appropriate scale CPC platform to meet their highest standards. Once the CPC is delivered, RotaChrom’s qualified engineering team installs the instrument according to the site acceptance test protocol and trains the Partner’s staff to use the instrument efficiently and independently.

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Customer Technical Support – at your service anytime!

RotaChrom’s professional and devoted colleagues at the Customer Technical Support Department are a phone call away to give you the quickest and highest standard service possible whenever and wherever you may need it. Installation & Maintenance Manuals, Product Datasheets and Site Requirement documents are provided to all RotaChrom Partners. Preventative maintenance schedules and a list of wearing parts will also be offered to minimize down-time and maximize the instrument’s reliability. RotaChrom’s Service & Maintenance professionals are ready to eliminate all technical obstacles from the way of lucrative business worldwide.

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On-Site Consultancy: New Method or Scale-Up Development

If the Partners require additional professional guidance, RotaChrom’s Technical Support Team provides high-standard consultancy services all over the world. Whether New Method Development or Scale-Up development is needed, RotaChrom’s trained and experienced Technical Support Representatives are at your service on-site.

Let's begin the cooperation!

Send RotaChrom a message

product-dev | Rotachrom Technologies LLC.