Through the platforms RotaChrom offers, manufacturers have no limits on adapting the system for new downstream challenges from small molecule APIs to macromolecules or from hydrophobic lipids to completely hydrophilic peptides all on the same machine.
Why invest in
a RotaChrom CPC platform?
Zero Silica Gel in
the Purification Process
RotaChrom CPC platform does not utilize any solid stationary phase, like normal phase or reversed phase silica, in order to achieve efficient industrial scale mixture separation.
High Resolution
Performance
The CPC platform has been proven superior to preparative HPLC, SMB, Ion exchange, Flash chromatography, crystallization, as well as chiral chromatography in terms of purity, yield, and return on investment.
Adaptability
and Scale-Up
The CPC system has almost no limits on adaptation from small molecule APIs to macromolecules or from hydrophobic lipids to completely hydrophilic peptides on the same instrument.
Exceptional Quality
RotaChrom staff is well-skilled in quality assurance, risk management, Good Validation and Qualification Practice in order to apply and implement standard operation procedures in Client working environment.
- Conventional industrial LC*RotaChrom industrial CPC
- High solvent consumptionLess solvent consumption
- Expensive stationary phase; difficult column fillingNo solid bulk material; Solvents with higher impurities can be utilized
- Only the mobile phase is recyclable Both phases are >95% recyclable (organic solvents)
- Irreversible adsorption denaturation No irreversibility detected
- Difficult scale-up – complete redesign needed Easy scale up from grams/batch to tons/month production in weeks
- Limited adaptation for different application (major change of instrument needed for different application) Almost no limits on adaptation from small molecule APIs to macromolecules from extremely hydrophobic lipids to completely hydrophilic peptides
- Yield limited due to multi-step processes Allows much fewer steps resulting in much higher yields and technical grade solvents can also be used
- Long retention time and lower productivityShorter retention times through customized solvent system composition which results higher productivity
* Liquid chromatography
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