Silica, the costly byproduct…
During the preparative-scale high performance liquid chromatography, separation is conducted through silica-based stationary phase, utilizing organic solvent based mobile phase. The most common issues are the compounds that are irreversibly bound in the system, and, as the result of pressure, silica degradation. Frequent silica regeneration cycle or replacement significantly increases the maintenance expenditures.
One of the ample benefits of the Rotachrom iCPC technology is that it is a sustainable approach by that it does not require the usage of expensive and polluting silica gel as it does not utilize any solid stationary phase in order to achieve crude purification.
Rotachrom’s Centrifugal Partition Chromatography (CPC) technology requires far less solvent consumption than comparative methods. What’s more, a staggering 95% of the solvent material is recoverable and reusable in the system.
Instead of HPLC grade solvents, this iCPC system merely requires technical grade solvents to perform industrial scale GMP compliant precision separation.
Bidding farewell to silica: Our Zero Silica Gel principle throughout in the Purification Process means that the total consumables when applying an iCPC system, can be substantially reduced and could be even decimated if a RotaChrom’ tailor-made solvent recovery system is in place.
#1. No replacement of columns & cartridges, easy to scale up from grams to kilograms
#2. Recycled solvents = lower consumable costs
#3. Higher flow rates = shorter run times
#4. Low consumable costs: <95%+ recyclable liquid-liquid solvent system
#5. Scalability: Direct scale-up from 2 kg/day (rCPC) to 20 kg/day (iCPC)
#6. Automated operation: PLC-controlled platform keeping labor costs low
#7. Future-proof technology: Adapt quickly to any future separation needs
#8. Salvage the mother liquor and repurpose it as a valuable input material for various new revenue streams
#9. Mixology: isolate, separate, and then remix compounds of interest and create new undiscovered sensations
#10 Compliance: Designed to adhere to relevant industry standards and directives providing robust and reliable operation. Our team members with significant pharma industry experience also deliver tailor-made regulatory compliant solutions.
RotaChrom at MJBizCon
Have you been wanting to ask about Rotachrom solutions in person? Schedule a meeting or just join us at booth C4818 at MJBizCon2021 to get an up-close look at our signature products, including: iCPC, rCPC, pCPC.
