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Precision Performance

In the iCPC process development, biphasic systems can be catered and optimized for specific purification challenges and the results have been groundbreaking (please see examples in the publications section).

The platform has demonstrated superiority to traditional LC systems such as HPLC, SMB, flash, Ion Exchange and EVEN Chiral Chromatography as well as multistep crystallization in most cases in terms of yield, purity, cost, and return of investment. 

Dramatic Reduction of Steps - Increased Yield

The iCPC platform drastically reduces the number of steps in the downstream process which translates to lower costs and higher yield. The following 5 case studies demonstrate how the iCPC system achieved a dramatic increase in yield and profitability while reducing costs. 

 

iCPC DRASTICALLY REDUCES THE STEPS OF DOWNSTREAM PROCESSING

COMPOUND
EXAMPLES

OLD PURIFICATION METHOD

ROTACHROM METHOD

 Prostaglandin

10 recrystallization + 3 column chromatography

CPC + 2 recrystallization

 Omega-3 acids

Reversed-phase SMB + column chromatography

Single step CPC

 Oligopeptide

2 column chromatography + 3 recrystallization

CPC + 1 recrystallization

 Oligopeptide

14 extraction + 2 recrystallization

CPC + 1 recrystallization

 Taxane

MPLC + Column chromatography

Single step CPC

DRAMATIC REDUCTION IN STEPS
MEANS INCREASED YIELD,
PROFITABILITY & COST-EFFECTIVENESS.

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Contact us

If you have a questions, please feel free to contact us!

E-mail: info[at]rotachrom.com
Tel.: +36 70 885 6922

Office and Application Laboratory

H-2370
Dabas, Fő út 151.
Magyarország - Hungary